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Radha Rama Devi, A. and Prabhakara, K. and Dutta, Usha (2002) Familial (11;21)(p13;q22)pat balanced reciprocal translocation in a female child with regression of milestones. Annales de Génétique, 45 (1). pp. 13-5. ISSN 0003-3995

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Abstract

The role of balanced translocations in the human morphogenesis is difficult to interpret. A balanced reciprocal translocation (BRT) was observed in a female child referred with a history of regression of milestones. The cytogenetic findings by GTG-banding and fluorescence in situ hybridization revealed a BRT involving chromosomes 11p and 21q, i.e. 46,XX, t(11;21)(p13;q22). The father was found to be a carrier of the same BRT. This is the first report of reciprocal translocation involving 11p and 21q. The possible reasons for the manifestation of clinical features in the proband due to inherited BRT are discussed.

Item Type: Article
Subjects: Genetics
Depositing User: Dr P Divakar
Date Deposited: 02 Jun 2015 05:51
Last Modified: 02 Jun 2015 05:51
URI: http://cdfd.sciencecentral.in/id/eprint/127

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