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Hasnain, S.E. and Begum, R. and Ramaiah, K.V.A. and Sahdev, S. and Shajil, E.M. and Taneja, T.K. and Mohan, M. and Athar, M. and Sah, N.K. and Krishnaveni, M. (2003) Host-pathogen interactions during apoptosis. Journal of Biosciences, 28 (3). pp. 349-358. ISSN 0250-5991

J Biosci 28 p349.pdf

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Host pathogen interaction results in a variety of responses, which include phagocytosis of the pathogen, release of cytokines, secretion of toxins, as well as production of reactive oxygen species (ROS). Recent studies have shown that many pathogens exert control on the processes that regulate apoptosis in the host. The induction of apoptosis upon infection results from a complex interaction of parasite proteins with cellular host proteins. Abrogation of host cell apoptosis is often beneficial for the pathogen and results in a successful host invasion. However, in some cases, it has been shown that induction of apoptosis in the infected cells significantly imparts protection to the host from the pathogen. There is a strong correlation between apoptosis and the host protein translation machinery: the pathogen makes all possible efforts to modify this process so as to inhibit cell suicide and ensure that it can survive and, in some cases, establish latent infection. This review discusses the significance of various pathways/steps during virus-mediated modulation of host cell apoptosis.

Item Type: Article
Depositing User: Dr P Divakar
Date Deposited: 10 Jun 2015 11:06
Last Modified: 29 Nov 2015 17:57
URI: http://cdfd.sciencecentral.in/id/eprint/172

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