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Mukhopadhyay, Sangita and Srivastava, V.M.L. and Murthy, P.K. and Hasnain, S.E. (2004) Poorer NF-κB signaling by microfilariae in macrophages from BALB/c mice affects their ability to produce cytotoxic levels of nitric oxide to kill microfilariae. FEBS Letters, 567 (2-3). pp. 275-280. ISSN 0014-5793

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Upon activation with microfilariae (mf), macrophages from C57Bl/6 mice showed higher nuclear factor-κB (NF-κB) but lower activating protein 1 DNA-binding activity as compared to BALB/c macrophages. The C57Bl/6 macrophages produced cytotoxic levels of nitric oxide (NO) to kill Setaria cervi mf as compared to BALB/c macrophages. Inhibition of the NF-κB signal by pyrrolidine dithiocarbamate (PDTC) blocked NO production and microfilaricidal activity of C57Bl/6 macrophages and inclusion of the exogenous NO generator (SNP) in the PDTC treated C57Bl/6 macrophage cultures induced mf cytotoxicity. These results underscore that the NF-κB signal (induced in response to mf) is important for the NO-mediated microfilaricidal activity of macrophages.

Item Type: Article
Depositing User: Dr P Divakar
Date Deposited: 01 Jul 2015 09:19
Last Modified: 01 Jul 2015 09:19
URI: http://cdfd.sciencecentral.in/id/eprint/207

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