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Adduri, R.S.R. and Katamoni, R. and Pandilla, R. and Madana, S.N. and Paripati, A.K. and Kotapalli, V. and Bashyam, M.D. (2014) TP53 Pro72 allele is enriched in oral tongue cancer and frequently mutated in esophageal cancer in India. PloS one, 9 (12). e114002. ISSN 1932-6203

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Abstract

The tumor suppressor p53 is known to be inactivated frequently in various cancers. In addition, germline polymorphisms in TP53 are known to affect protein function and influence risk of developing different types of cancers. In this study, we analyzed the association of TP53 Pro72Arg polymorphism with squamous cell carcinoma of oral tongue (SCCOT) and esophagus (ESCC) in India. The study revealed the association of Pro72 allele with SCCOT suggesting the effect of this polymorphism on SCCOT risk. Preferential mutation of Pro72 allele exclusively in ESCC indicates the need for further studies to understand the tissue specific effect of p53 polymorphism.

Item Type: Article
Subjects: Genetics
Molecular Biology
Depositing User: Dr P Divakar
Date Deposited: 15 May 2015 05:54
Last Modified: 15 May 2015 05:54
URI: http://cdfd.sciencecentral.in/id/eprint/23

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