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Vijay Kumar, S. and Ranjan, Sarita and Saxena, V. and Rajesh, V. and Roy, S.K. and Kochar, D. and Ranjan, Akash and Das, A. (2005) Plasmodium falciparum: Genetic diversity of C-terminal region of MSP-1 in isolates from Indian sub-continent. Experimental Parasitology, 110 (4). pp. 384-388. ISSN 0014-4894

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Abstract

Malaria parasites exhibit sequence diversity for a number of stage specific antigens. Several studies have proved that merozoite surface protein-1 (MSP-1) is an effective target eliciting a protective immune response. The MSP-142 region comprising two EGF-like domains is involved in generating protective immune response in humans and other experimental animals. Searching for point mutations in this region is essential in view of vaccine development. We have investigated the sequence variations in Plasmodium falciparum MSP-1 carboxy terminal region in field isolates from different regions in India. Our study reveals the presence of eight variant types of MSP-119 in the Indian sub-continent, which comprise of E-TSR-L, Q-TSR-L, E-TSG-L, Q-KNG-L, Q-KNG-F, E-KNG-L, E-KNG-F, and E-KYG-F. The last named allele is a novel variant being reported for the first time.

Item Type: Article
Depositing User: Dr P Divakar
Date Deposited: 14 Jul 2015 09:37
Last Modified: 14 Jul 2015 09:37
URI: http://cdfd.sciencecentral.in/id/eprint/245

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