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Sechi, L.A. and Gazouli, M. and Ikonomopoulos, J. and Lukas, J.C. and Scanu, A.M. and Ahmed, N. and Fadda, G. and Zanetti, S. (2005) Mycobacterium avium subsp. paratuberculosis, Genetic Susceptibility to Crohn's Disease, and Sardinians: the Way Ahead. Journal of Clinical Microbiology, 43 (10). pp. 5275-5277. ISSN 0095-1137

J Clin Microbiol 43 p5275.pdf

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The present study was performed to determine what proportion of people in Sardinia with or without Crohn's disease were infected with Mycobacterium avium subspecies paratuberculosis and had a preponderance of allelic variants of Nod2, an intracellular protein involved in Crohn's disease susceptibility. Genetic analysis of the alleles of the NOD2/CARD15 gene (insC3020, G908R, and R702W alleles), linked to susceptibility or genetic predisposition to Crohn's disease in humans, was carried out on specimens from 37 Crohn's disease patients and 34 patients without Crohn's disease. Our results show that more than 70 percent of people in Sardinia with Crohn's disease carry at least one of the susceptibility-associated NOD2/CARD15 alleles and were infected with Mycobacterium avium subspecies paratuberculosis.

Item Type: Article
Depositing User: Dr P Divakar
Date Deposited: 15 Jul 2015 06:42
Last Modified: 01 Sep 2017 07:53
URI: http://cdfd.sciencecentral.in/id/eprint/248

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