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Manna, S.K. and Sarkar, S. and Barr, J. and Wise, K. and Barrera, E.V. and Jejelowo, O. and Rice-Ficht, A.C. and Ramesh, G.T. (2005) Single-Walled Carbon Nanotube Induces Oxidative Stress and Activates Nuclear Transcription Factor-κB in Human Keratinocytes. Nano Letters, 5 (9). pp. 1676-1684. ISSN 1530-6984

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Abstract

Carbon nanotubes are now becoming an important material for use in day to day life because of their unique physical properties. The toxicological impact of these materials has not yet been studied in detail, thereby limiting their use. In the present study, the toxicity of single-walled carbon nanotubes (SWCNT) was assessed in human keratinocyte cells. The results show increased oxidative stress and inhibition of cell proliferation in response to treatment of keratinocytes with SWCNT particles. In addition, the signaling mechanism in keratinocytes upon exposure to SWCNT particles was investigated. Results from the study suggest that SWCNT particles activate NF-κB in a dose-dependent manner in human keratinocytes. Further, the mechanism of activation of NF-κB was due to the activation of stress-related kinases by SWCNT particles in keratinocytes. In conclusion, these studies show the mechanism of toxicity induced by SWCNT particles.

Item Type: Article
Depositing User: Dr P Divakar
Date Deposited: 21 Jul 2015 06:50
Last Modified: 21 Jul 2015 06:50
URI: http://cdfd.sciencecentral.in/id/eprint/265

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