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Yellaboina, S. and Ranjan, Sarita and Vindal, V. and Ranjan, Akash (2006) Comparative analysis of iron regulated genes in mycobacteria. FEBS Letters, 580 (11). pp. 2567-2576. ISSN 0014-5793

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Iron dependent regulator, IdeR, regulates the expression of genes in response to intracellular iron levels in M. tuberculosis. Orthologs of IdeR are present in all the sequenced genomes of mycobacteria. We have used a computational approach to identify conserved IdeR regulated genes across the mycobacteria and the genes that are specific to each of the mycobacteria. Novel iron regulated genes that code for a predicted 4-hydroxy benzoyl coA hydrolase (Rv1847) and a protease dependent antibiotic regulatory system (Rv1846c, Rv0185c) are conserved across the mycobacteria. Although Mycobacterium natural-resistance-associated macrophage protein (Mramp) is present in all mycobacteria, it is, as predicted, an iron-regulated gene in only one species, M. avium subsp. paratuberculosis. We also observed an additional iron-regulated exochelin biosynthetic operon, which is present only in non-pathogenic Mycobacterium, M. smegmatis.

Item Type: Article
Depositing User: Dr P Divakar
Date Deposited: 22 Jul 2015 10:33
Last Modified: 24 Nov 2015 19:44
URI: http://cdfd.sciencecentral.in/id/eprint/282

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