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Gutierrez, M.C. and Ahmed, N. and Willery, E. and Narayanan, S. and Hasnain, S.E. and Chauhan, D.S. and Katoch, V.M. and Vincent, V. and Locht, C. and Supply, P. (2006) Predominance of Ancestral Lineages ofMycobacterium tuberculosisin India. Emerging Infectious Diseases, 12 (7). pp. 1367-1374. ISSN 1080-6040

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Abstract

Although India has the highest prevalence of tuberculosis (TB) worldwide, the genetic diversity of Mycobacterium tuberculosis in India is largely unknown. A collection of 91 isolates originating from 12 different regions spread across the country were analyzed by genotyping using 21 loci with variable-number tandem repeats (VNTRs), by spoligotyping, by principal genetic grouping (PGG), and by deletion analysis of M. tuberculosis–specific deletion region 1. The isolates showed highly diverse VNTR genotypes. Nevertheless, highly congruent groupings identified by using the 4 independent sets of markers permitted a clear definition of 3 prevalent PGG1 lineages, which corresponded to the "ancestral" East African–Indian, the Delhi, and the Beijing/W genogroups. A few isolates from PGG2 lineages and a single representative of the presumably most recent PGG3 were identified. These observations suggest a predominance of ancestral M. tuberculosis genotypes in the Indian subcontinent, which supports the hypothesis that India is an ancient endemic focus of TB.

Item Type: Article
Depositing User: Dr P Divakar
Date Deposited: 30 Jul 2015 11:21
Last Modified: 30 Jul 2015 11:21
URI: http://cdfd.sciencecentral.in/id/eprint/313

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