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Manna, S.K. and Aggarwal, R.S. and Sethi, G. and Aggarwal, B.B. and Ramesh, G.T. (2007) Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis. Clinical Cancer Research, 13 (7). pp. 2290-7. ISSN 1078-0432

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Abstract

Morin is a flavone that exhibits antiproliferative, antitumor, and anti-inflammatory effects through a mechanism that is not well understood. Because of the role of transcription factor nuclear factor-kappaB (NF-kappaB) in the control of cell survival, proliferation, tumorigenesis, and inflammation, we postulated that morin mediates its effects by modulating NF-kappaB activation.

Item Type: Article
Depositing User: Dr P Divakar
Date Deposited: 17 Aug 2015 05:00
Last Modified: 17 Aug 2015 05:00
URI: http://cdfd.sciencecentral.in/id/eprint/338

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