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Bose, J.S. and Gangan, V. and Jain, S.K. and Manna, S.K. (2009) Downregulation of Inflammatory Responses by Novel Caffeic Acid Ester Derivative by Inhibiting NF-kappa B. Journal of Clinical Immunology, 29 (1). pp. 90-98. ISSN 0271-9142

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Abstract

INTRODUCTION: Considering anti-tumorigenic activity of caffeic acid phenyl ester, synthesis of several esterified form of caffeic acid is a novel approach in designing for potent drugs. RESULTS: Our study demonstrates that esterified caffeic acid with methyl vanillate, termed as caffeic acid methyl vanillate ester (CAMVE), blocked inflammatory stimuli-induced inflammatory responses. It decreased amounts of iNOS, Cox-2, and ICAM1 by inhibiting NF-kappaB through inhibition of IKK activity, I kappaB alpha degradation, and p65 nuclear translocation. CONCLUSION: Overall, our data suggest that novel caffeic acid ester down-regulates inflammatory responses through inhibition of NF-kappaB and dependent several gene expressions, further suggesting its efficacy as a promising therapeutic agent.

Item Type: Article
Depositing User: Dr P Divakar
Date Deposited: 26 Aug 2015 09:54
Last Modified: 26 Aug 2015 09:54
URI: http://cdfd.sciencecentral.in/id/eprint/388

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