Bose, J.S. and Gangan, V. and Jain, S.K. and Manna, S.K. (2009) Novel caffeic acid ester derivative induces apoptosis by expressing fasl and downregulating NF-KappaB: Potentiation of cell death mediated by chemotherapeutic agents. Journal of Cellular Physiology, 218 (3). pp. 653-662. ISSN 0021-9541

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Abstract

In the present study, we demonstrate the biological activity of esterified caffeic acid with methyl vanillate also termed as caffeic acid methyl vanillate ester (CAMVE). CAMVE potentiates TNF-induced cell death as analyzed by cell viability assay and blocks inflammatory stimuli-induced nuclear transcription factor kappaB (NF-kappaB) activation and NF-kappaB-dependent genes expression. CAMVE-mediated inhibition of NF-kappaB or induction of cell death is not cell type specific. CAMVE inhibits cell proliferation by inhibiting G1 to S phase progression. It suppresses TNF-induced Bcl-2 expression and potentiates chemotherapeutic agents-mediated cell death. CAMVE enhances intracellular free Ca(2+) and thereby activates calcineurin. Calcineurin, in turns, activates nuclear transcription factor NF-AT and its dependent genes such as FasL, which induces cell death. The data demonstrate that CAMVE is one of the combinatorial products, which is able to inhibit NF-kappaB regulated genes and cell proliferation. The combinatorial synthesis of novel caffeic ester derivatives can be a useful approach to generate potent chemotherapeutic agents and designing CAMVE as potent therapeutic agent for combination therapy may be useful to treat tumors.

Item Type:	Article
Depositing User:	Users 2 not found.
Date Deposited:	26 Aug 2015 10:02
Last Modified:	26 Aug 2015 10:02
URI:	http://cdfd.sciencecentral.in/id/eprint/389

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