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Manna, S.K. and Babajan, B. and Raghavendra, P.B. and Raviprakash, N. and Suresh Kumar, C. (2010) Inhibiting TRAF2-mediated Activation of NF- B Facilitates Induction of AP-1. Journal of Biological Chemistry, 285 (15). pp. 11617-11627. ISSN 0021-9258

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Abstract

The compound 5-(4-methoxyarylimino)-2-N-(3,4-dichlorophenyl)-3-oxo-1,2,4-thiadiazolidine (P3-25) is known to possess anti-bacterial, anti-fungal, and anti-tubercular activities. In this report, we provide evidence that P3-25 inhibits NF-κB, known to induce inflammatory and tumorigenic responses. It activates AP-1, another transcription factor. It inhibits TRAF2-mediated NF-κB activation but not TRAF6-mediated NF-κB DNA binding by preventing its association with TANK (TRAF for NF-κB). It facilitates binding of MEKK1 with TRAF2 and thereby activates JNK and AP-1. We provide evidence, for the first time, that suggests that the interaction of P3-25 with TRAF2 leads to inhibition of the NF-κB pathway and activation of AP-1 pathway. These results suggest novel approaches to design of P3-25 as an anti-cancer/inflammatory drug for therapy through regulation of the TRAF2 pathway.

Item Type: Article
Additional Information: [Open Access from the Publisher]
Depositing User: Dr P Divakar
Date Deposited: 28 Aug 2015 04:50
Last Modified: 16 Dec 2015 06:57
URI: http://cdfd.sciencecentral.in/id/eprint/407

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