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Sinha, A. and Nagarajaram, H.A. (2014) Nodes occupying central positions in human tissue specific PPI networks are enriched with many splice variants. Proteomics, 14 (20). pp. 2242-2248. ISSN 1615-9853

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The functional repertoire of genes in the eukaryotic organisms is enhanced by the phenomenon of alternative splicing. Hence, a node in a tissue specific protein-protein interaction (TS PPIN) network can be thought of as an ensemble of various spliced protein products of the corresponding gene expressed in that tissue. Here we demonstrate that the nodes that occupy topologically central positions characterized by high degree, betweenness, closeness, and eigenvector centrality values in TS PPINs of Homo sapiens are associated with high number of splice variants. We also show that the high "centrality" of these genes/nodes could in part be explained by the presence of a large number of promiscuous domains.

Item Type: Article
Uncontrolled Keywords: Alternative splicing; Bioinformatics; Domain−domain interaction; Protein–protein interactions; RNA-seq; Tissue-specific
Subjects: Computational Biology
Developmental Biology
Depositing User: Dr P Divakar
Date Deposited: 16 May 2015 20:09
Last Modified: 27 Oct 2015 08:15
URI: http://cdfd.sciencecentral.in/id/eprint/41

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