Manderwad, G.P. and Gokul, G. and Kannabiran, C. and Honavar, S.G. and Khosla, Sanjeev and Vemuganti, G.K. (2010) Hypomethylation of the DNMT3L promoter in ocular surface squamous neoplasia. Archives of Pathology & Laboratory Medicine, 134 (8). pp. 1193-6. ISSN 1543-2165

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Abstract

Cancer is known to have epigenetic inputs, with events like genomewide hypomethylation and gene-specific hypermethylation of DNA. The DNA methyltransferase enzymes act as effectors of this reprogramming. A previous study revealed that hypomethylation at the DNA methyltransferase 3-like (DNMT3L) promoter could be a potential biomarker in cervical tumors. Because the pathobiology of ocular surface squamous neoplasia (OSSN) is similar to that of cervical tumors, we wanted to determine whether similar changes occur in the methylation pattern at the DNMT3L promoter in OSSN.

Item Type:	Article
Depositing User:	Users 2 not found.
Date Deposited:	01 Sep 2015 05:32
Last Modified:	01 Sep 2015 05:32
URI:	http://cdfd.sciencecentral.in/id/eprint/421

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