Alvi, A. and Devi, S.M. and Ahmed, I. and Hussain, M.A. and Rizwan, M. and Lamouliatte, H. and Megraud, F. and Ahmed, N. (2007) Microevolution of Helicobacter pylori Type IV Secretion Systems in an Ulcer Disease Patient over a Ten-Year Period. Journal of Clinical Microbiology, 45 (12). pp. 4039-4043. ISSN 0095-1137

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Abstract

Helicobacter pylori cagA and vacA genotypes have been used for almost a decade as stable entities to link the severity of gastritis and ulcer disease. We describe here microevolution of the two genomic islands, cag pathogenicity island (cagPAI; 40 kb) and tfs3 (16 kb) from isolates obtained at inclusion (one subclone) and after a 10-year period (two subclones) from a duodenal ulcer patient. Our results indicate microevolution in cagA, cagE, and cag7 genes of the cagPAI and open reading frames G, P, and L in tfs3, which possibly leads to inactivation or pseudogenization of these genes. Interestingly, no significant reduction in the severity of gastroduodenal pathology was found. These results point to an obvious difficulty in correlating the continuously evolving virulence factors such as the cagPAI genes with disease characteristics that appear to remain stable

Item Type:	Article
Depositing User:	Users 2 not found.
Date Deposited:	23 Oct 2015 10:43
Last Modified:	23 Oct 2015 10:43
URI:	http://cdfd.sciencecentral.in/id/eprint/564

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