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Thangaraj, K. and Gupta, N.J. and Chakravarty, B. and Singh, Lalji (1998) A 47, XXY female. The Lancet, 352 (9134). p. 1121. ISSN 0140-6736

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Abstract

Klinefelter syndrome (47, XXY) with male phenotype is the most common sex chromosomal abnormality.2 It is believed that SRY (sex determining region on Y) is the major gene necessary to induce the undifferentiated bipotential gonadal primordium to develop as testis.2 Recently, several SRY-box-related (SOX) genes have been identified on autosomes.3 Mutations in the SRY or SOX gene have been implicated in sex reversal.4 We report an individual having 47, XXY chromosome constitution, normal SRY, SOX9, and ZFY genes and yet with a female phenotype

Item Type: Article
Depositing User: Dr P Divakar
Date Deposited: 02 Nov 2015 18:21
Last Modified: 06 Apr 2016 04:06
URI: http://cdfd.sciencecentral.in/id/eprint/613

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