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Sechi, L.A. and Ruehl, A. and Ahmed, N. and Usai, D. and Paccagnini, D. and Felis, G.E. and Zanetti, S. (2007) Mycobacterium aviumsubspeciesparatuberculosisinfects and multiplies in enteric glial cells. World Journal of Gastroenterology, 13 (43). pp. 5731-5735. ISSN 1007-9327

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Abstract

AIM: To establish the role of enteric glial cells during infection with Mycobacterium avium subspecies paratuberculosis (MAP) in Crohn’s disease. METHODS: In order to establish the role of enteric glial cells during infection with M. avium subspecies paratuberculosis (MAP) in Crohn’s disease, Map adhesion experiments on enteric glial cells were performed as well as expression analysis of Map sigma factors during infection. RESULTS: In this study, for the first time, we found a high affinity of MAP to enteric glial cells and we analyzed the expression of MAP sigma factors under different conditions of growth. CONCLUSION: The fact that Map showed a high affinity to the glial cells raises concerns about the complicated etiology of the Crohn’s disease. Elucidation of the mechanisms whereby inflammation alters enteric neural control of gut functions may lead to novel treatments for Crohn’s disease.

Item Type: Article
Additional Information: [Open Access from the Publisher]
Depositing User: Dr P Divakar
Date Deposited: 17 Nov 2015 06:18
Last Modified: 30 Jul 2018 12:16
URI: http://cdfd.sciencecentral.in/id/eprint/643

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