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Vedantham, H. and Silver, M.I. and Kalpana, B. and Rekha, C. and Karuna, B.P. and Vidyadhari, K. and Mrudula, S. and Ronnett, B.M. and Vijayaraghavan, K. and Ramakrishna, Gayatri and Sowjanya, A.P. and Laxmi, S. and Shah, K.V. and Gravitt, P.E. (2010) Determinants of VIA (Visual Inspection of the Cervix After Acetic Acid Application) Positivity in Cervical Cancer Screening of Women in a Peri-Urban Area in Andhra Pradesh, India. Cancer Epidemiology Biomarkers & Prevention, 19 (5). pp. 1373-1380. ISSN 1055-9965

Cancer Epidemiol 19 p1373.pdf

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Objectives: Visual inspection of the cervix after acetic acid application (VIA) is widely recommended as the method of choice in cervical cancer screening programs in resource-limited settings because of its simplicity and ability to link with immediate treatment. In testing the effectiveness of VIA, human papillomavirus DNA testing, and Pap cytology in a population-based study in a peri-urban area in Andhra Pradesh, India, we found the sensitivity of VIA for detection of cervical intraepithelial neoplasia grade 2 and worse (CIN2+) to be 26.3%, much lower than the 60% to 90% reported in the literature. We therefore investigated the determinants of VIA positivity in our study population. Methods: We evaluated VIA positivity by demographics and reproductive history, results of clinical examination, and results from the other screening methods. Results: Of the 19 women diagnosed with CIN2+, only 5 were positive by VIA (positive predictive value, 3.1%). In multivariate analysis, VIA positivity (12.74%) was associated with older age, positive Pap smear, visually apparent cervical inflammation, and interobserver variation. Cervical inflammation of unknown cause was present in 21.62% of women. In disease-negative women, cervical inflammation was associated with an increase in VIA positivity from 6.1% to 15.5% (P < 0.001). Among the six gynecologists who performed VIA, the positivity rate varied from 4% to 31%. Conclusions: The interpretation of VIA is subjective and its performance cannot be readily evaluated against objective standards

Item Type: Article
Depositing User: Dr P Divakar
Date Deposited: 19 Nov 2015 08:41
Last Modified: 19 Nov 2015 08:41
URI: http://cdfd.sciencecentral.in/id/eprint/656

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