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Kumar, Raviranjan and Chotaliya, M. and Sruthakeerthi, V. and Auradkar, A. and Kalyani, P. and Joshi, Rohit (2015) Role of Homothorax in region specific regulation of Deformed in embryonic neuroblasts. Mechanisms of Development, 138 (2). pp. 190-197. ISSN 0925-4773

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Abstract

The expression and regulation of Hox genes in developing central nervous system (CNS) lack important details like specific cell types where Hox genes are expressed and the transcriptional regulatory players involved in these cells. In this study we have investigated the expression and regulation of Drosophila Hox gene Deformed (Dfd) in specific cell types of embryonic CNS. Using Dfd neural autoregulatory enhancer we find that Dfd autoregulates itself in cells of mandibular neuromere. We have also investigated the role of a Hox cofactor Homothorax (Hth) for its role in regulating Dfd expression in CNS. We find that Hth exhibits a region specific role in controlling the expression of Dfd, but has no direct role in mandibular Dfd neural autoregulatory circuit. Our results also suggest that homeodomain of Hth is not required for regulating Dfd expression in embryonic CNS.

Item Type: Article
Additional Information: Open Access from the Official URL
Depositing User: Dr P Divakar
Date Deposited: 08 Dec 2015 09:36
Last Modified: 03 Feb 2018 11:55
URI: http://cdfd.sciencecentral.in/id/eprint/690

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