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Ballantyne, K.N. and Ralf, A. and Aboukhalid, R. and Achakzai, N.M. and Anjos, M.J. and Ayub, Q. and Balažic, J. and Ballantyne, J. and Ballard, D.J. and Berger, B. and Bobillo, C. and Bouabdellah, M. and Burri, H. and Capal, T. and Caratti, S. and Cárdenas, J. and Cartault, F. and Carvalho, E.F. and Carvalho, M. and Cheng, B. and Coble, M.D. and Comas, D. and Corach, D. and D'Amato, M.E. and Davison, S. and de Knijff, P. and De Ungria, M.C.A. and Decorte, R. and Dobosz, T. and Dupuy, B.M. and Elmrghni, S. and Gliwiński, M. and Gomes, S.C. and Grol, L. and Haas, C. and Hanson, E. and Henke, J. and Henke, L. and Herrera-Rodríguez, F. and Hill, C.R. and Holmlund, G. and Honda, K. and Immel, U.D. and Inokuchi, S. and Jobling, M.A. and Kaddura, M. and Kim, J.S. and Kim, S.H. and Kim, W. and King, T.E. and Klausriegler, E. and Kling, D. and Kovačević, L. and Kovatsi, L. and Krajewski, P. and Kravchenko, S. and Larmuseau, M.H.D. and Lee, E.Y. and Lessig, R. and Livshits, L.A. and Marjanović, D. and Minarik, M. and Mizuno, N. and Moreira, H. and Morling, N. and Mukherjee, M. and Munier, P. and Nagaraju, J. and Neuhuber, F. and Nie, S. and Nilasitsataporn, P. and Nishi, T. and Oh, H.H. and Olofsson, J. and Onofri, V. and Palo, J.U. and Pamjav, H. and Parson, W. and Petlach, M. and Phillips, C. and Ploski, R. and Prasad, S.P.R. and Primorac, D. and Purnomo, G.A. and Purps, J. and Rangel-Villalobos, H. and Rębała, K. and Rerkamnuaychoke, B. and Gonzalez, D.R. and Robino, C. and Roewer, L. and Rosa, A. and Sajantila, A. and Sala, A. and Salvador, J.M. and Sanz, P. and Schmitt, C. and Sharma, A.K. and Silva, D.A. and Shin, K.J. and Sijen, T. and Sirker, M. and Siváková, D. and Skaro, V. and Solano-Matamoros, C. and Souto, L. and Stenzl, V. and Sudoyo, H. and Syndercombe-Court, D. and Tagliabracci, A. and Taylor, D. and Tillmar, A. and Tsybovsky, I.S. and Tyler-Smith, C. and van der Gaag, K.J. and Vanek, D. and Völgyi, A. and Ward, D. and Willemse, P. and Yap, E.P.H. and Yong, R.Y.Y. and Pajnič, I.Z. and Kayser, M. (2014) Toward male individualization with rapidly mutating y-chromosomal short tandem repeats. Human Mutation, 35 (8). pp. 1021-32. ISSN 1098-1004

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Abstract

Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836-0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father-son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database.

Item Type: Article
Subjects: Cell Biology
Depositing User: Dr P Divakar
Date Deposited: 22 May 2015 07:48
Last Modified: 25 May 2015 10:14
URI: http://cdfd.sciencecentral.in/id/eprint/76

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