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Shah, Akruti and Ganguli, S. and Sen, J. and Bhandari, Rashna (2017) Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules. Journal of the Indian Institute of Science, 97 (1). pp. 23-40. ISSN 0970-4140

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Inositol pyrophosphates (PP-IPs) are a class of energy-rich signalling molecules found in all eukaryotic cells. These are derivatives of inositol that contain one or more diphosphate (or pyrophosphate) groups in addition to monophosphates. The more abundant and best studied PP-IPs are diphosphoinositol pentakisphosphate (IP7) and bis-diphosphoinositol tetrakisphosphate (IP8). These molecules can influence protein function by two mechanisms: binding and pyrophosphorylation. The former involves the specific interaction of a particular inositol pyrophosphate with a binding site on a protein, while the latter is a unique attribute of inositol pyrophosphates, wherein the β-phosphate moiety is transferred from a PP-IP to a pre-phosphorylated serine residue in a protein to generate pyrophosphoserine. Both these events can result in changes in the target protein’s activity, localisation or its interaction with other partners. As a consequence of their ubiquitous presence in all eukaryotic organisms and all cell types examined till date, and their ability to modify protein function, PP-IPs have been found to participate in a wide range of metabolic, developmental, and signalling pathways. This review highlights many of the known functions of PP-IPs in the context of their temporal and spatial distribution in eukaryotic cells.

Item Type: Article
Depositing User: Dr P Divakar
Date Deposited: 16 Jun 2017 08:04
Last Modified: 16 Jun 2017 09:44
URI: http://cdfd.sciencecentral.in/id/eprint/780

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