[feed] Atom [feed] RSS 1.0 [feed] RSS 2.0

Khandelwal, Risha and Sipani, Rashmi and Sriivatsan, G.R. and Kumar, Raviranjan and Joshi, Rohit (2017) Combinatorial action of Grainyhead, Extradenticle and Notch in regulating Hox mediated apoptosis in Drosophila larval CNS. PLOS Genetics, 13 (10). e1007043. ISSN 1553-7404

[img]
Preview
Text
PLoS Genet 13 e1007043.pdf

Download (42Mb) | Preview

Abstract

Hox mediated neuroblast apoptosis is a prevalent way to pattern larval central nervous system (CNS) by different Hox genes, but the mechanism of this apoptosis is not understood. Our studies with Abdominal-A (Abd-A) mediated larval neuroblast (pNB) apoptosis suggests that AbdA, its cofactor Extradenticle (Exd), a helix-loop-helix transcription factor Grainyhead (Grh), and Notch signaling transcriptionally contribute to expression of RHG family of apoptotic genes. We find that Grh, AbdA, and Exd function together at multiple motifs on the apoptotic enhancer. In vivo mutagenesis of these motifs suggest that they are important for the maintenance of the activity of the enhancer rather than its initiation. We also find that Exd function is independent of its known partner homothorax in this apoptosis. We extend some of our findings to Deformed expressing region of sub-esophageal ganglia where pNBs undergo a similar Hox dependent apoptosis. We propose a mechanism where common players like Exd-Grh-Notch work with different Hox genes through region specific enhancers to pattern respective segments of larval central nervous system.

Item Type: Article
Depositing User: Dr P Divakar
Date Deposited: 20 Oct 2017 10:29
Last Modified: 21 Dec 2018 08:51
URI: http://cdfd.sciencecentral.in/id/eprint/799

Actions (login required)

View Item View Item