Cheng, T. and Wu, J. and Wu, Y. and Rajendra, C.V. and Huang, L. and Yamamoto, K. and Feng, Li and Li, W. and Chen, Z. and Guo, H. and Liu, J. and Li, S. and Wang, X. and Peng, Li and Liu, D. and Guo, Y. and Fu, B. and Li, Z. and Liu, C. and Chen, Y. and Tomar, A. and Hilliou, F. and Montagné, N. and Jacquin-Joly, E. and d’Alençon, E. and Seth, R.K. and Bhatnagar, R.K. and Jouraku, A. and Shiotsuki, T. and Kadono-Okuda, K. and Promboon, A. and Smagghe, G. and Arunkumar, K.P. and Kishino, H. and Goldsmith, M.R. and Feng, Q. and Xia, Q. and Mita, K. (2017) Genomic adaptation to polyphagy and insecticides in a major East Asian noctuid pest. Nature Ecology & Evolution, 1 (11). pp. 1747-1756. ISSN 2397-334X

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Abstract

The tobacco cutworm, Spodoptera litura, is among the most widespread and destructive agricultural pests, feeding on over 100 crops throughout tropical and subtropical Asia. By genome sequencing, physical mapping and transcriptome analysis, we found that the gene families encoding receptors for bitter or toxic substances and detoxification enzymes, such as cytochrome P450, carboxylesterase and glutathione-S-transferase, were massively expanded in this polyphagous species, enabling its extraordinary ability to detect and detoxify many plant secondary compounds. Larval exposure to insecticidal toxins induced expression of detoxification genes, and knockdown of representative genes using short interfering RNA (siRNA) reduced larval survival, consistent with their contribution to the insect’s natural pesticide tolerance. A population genetics study indicated that this species expanded throughout southeast Asia by migrating along a South India–South China–Japan axis, adapting to wide-ranging ecological conditions with diverse host plants and insecticides, surviving and adapting with the aid of its expanded detoxification systems. The findings of this study will enable the development of new pest management strategies for the control of major agricultural pests such as S. litura.

Item Type:	Article
Depositing User:	Users 2 not found.
Date Deposited:	20 Oct 2017 10:42
Last Modified:	27 Dec 2018 19:35
URI:	http://cdfd.sciencecentral.in/id/eprint/800

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