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Mitra, Pallabi and Ghosh, Gairika and Hafeezunnisa, Md. and Sen, Ranjan (2017) Rho Protein: Roles and Mechanisms. Annual Review of Microbiology, 71 (1). pp. 687-709. ISSN 0066-4227

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At the end of the multistep transcription process, the elongating RNA polymerase (RNAP) is dislodged from the DNA template either at specific DNA sequences, called the terminators, or by a nascent RNA-dependent helicase, Rho. In Escherichia coli, about half of the transcription events are terminated by the Rho protein. Rho utilizes its RNA-dependent ATPase activities to translocate along the mRNA and eventually dislodges the RNAP via an unknown mechanism. The transcription elongation factor NusG facilitates this termination process by directly interacting with Rho. In this review, we discuss current models describing the mechanism of action of this hexameric transcription terminator, its regulation by different cis and trans factors, and the effects of the termination process on physiological processes in bacterial cells, particularly E. coli and Salmonella enterica Typhimurium.

Item Type: Article
Depositing User: Dr P Divakar
Date Deposited: 20 Oct 2017 20:20
Last Modified: 29 Nov 2017 10:41
URI: http://cdfd.sciencecentral.in/id/eprint/801

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