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Singh, Parul and Nagender Rao, R. and Ghosh, Sudip and Mukhopadhyay, Sangita (2018) Cell envelope lipids in the pathophysiology of Mycobacterium tuberculosis. Future Microbiology, 13 (6). pp. 689-710. ISSN 1746-0913

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Abstract

Mycobacterium tuberculosis is an intracellular bacterium that persists and replicates inside macrophages. The bacterium possesses an unusual lipid-rich cell envelope that provides a hydrophobic impermeable barrier against many environmental stressors and allows it to survive extremely hostile intracellular surroundings. Since the lipid-rich envelope is crucial for M. tuberculosis virulence, the components of the cell wall lipid biogenesis pathways constitute an attractive target for the development of vaccines and antimycobacterial chemotherapeutics. In this review, we provide a detail description of the mycobacterial cell envelope lipid components and their contributions to the physiology and pathogenicity of mycobacteria. We also discussed the current status of the antimycobacterial drugs that target biosynthesis, export and regulation of cell envelope lipids.

Item Type: Article
Depositing User: Dr P Divakar
Date Deposited: 19 May 2018 19:59
Last Modified: 12 Jul 2018 16:56
URI: http://cdfd.sciencecentral.in/id/eprint/846

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