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Kasbekar, D.P. (2018) A cross-eyed geneticist’s view. Journal of Biosciences, 43 (2). pp. 235-237. ISSN 0250-5991
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Abstract
The vertebrate inner nuclear membrane protein, lamin B receptor, has an N-terminal ~200 residue nucleoplasmic domain (NTD), and a ~420 residue C-terminal domain (CTD) that anchors the NTD to the INM. Chen et al (2016) showed the NTD interacts with Xist long noncoding RNA to effect X chromosome inactivation in female mammals. Tsai et al (2016) showed the CTD has sterol reductase activity that is essential for viability. And Nikolakaki et al (2017) proposed a model to interconnect these disparate functions of this chimeric protein. It amuses me now to think back to 24 years ago, when I was concerned that these domains might have come together in a cloning artifact.
| Item Type: | Article |
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| Uncontrolled Keywords: | Lamin B receptor; Chimeric protein |
| Depositing User: | Users 2 not found. |
| Date Deposited: | 24 May 2018 17:45 |
| Last Modified: | 07 Jun 2018 11:42 |
| URI: | http://cdfd.sciencecentral.in/id/eprint/849 |
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