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Kumar, Kundan and Askari, Fizza and Sahu, Mahima and Kaur, Rupinder (2019) Candida glabrata: A Lot More Than Meets the Eye. Microorganisms, 7 (2). p. 39. ISSN 2076-2607

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Abstract

Candida glabrata is an opportunistic human fungal pathogen that causes superficial mucosal and life-threatening bloodstream infections in individuals with a compromised immune system. Evolutionarily, it is closer to the non-pathogenic yeast Saccharomyces cerevisiae than to the most prevalent Candida bloodstream pathogen, C. albicans. C. glabrata is a haploid budding yeast that predominantly reproduces clonally. In this review, we summarize interactions of C. glabrata with the host immune, epithelial and endothelial cells, and the ingenious strategies it deploys to acquire iron and phosphate from the external environment. We outline various attributes including cell surface-associated adhesins and aspartyl proteases, biofilm formation and stress response mechanisms, that contribute to the virulence of C. glabrata. We further discuss how, C. glabrata, despite lacking morphological switching and secreted proteolytic activity, is able to disarm macrophage, dampen the host inflammatory immune response and replicate intracellularly.

Item Type: Article
Uncontrolled Keywords: Candida glabrata; adherence; aspartyl proteases; biofilm formation; host immune cells; stress response mechanisms; yeast pathogens
Depositing User: Dr P Divakar
Date Deposited: 04 Feb 2019 07:53
Last Modified: 04 Feb 2019 07:53
URI: http://cdfd.sciencecentral.in/id/eprint/882

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