Ramasarma, T. and Vaigundan, D. (2019) Connecting CuA with metal centers of heme a, heme a, CuB and Zn by pathways with hydrogen bond as the bridging element in cytochrome c oxidase. Biochemical and Biophysical Research Communications, 510 (2). pp. 261-265. ISSN 0006-291X

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Abstract

Pathways formed of delocalized π-electron systems and polar groups of polypeptide chains bridged by hydrogen bonds are referred as π-H pathways. Suitable for electron transfer, these pathways in cytochrome c oxidase connect CuA, the source of electrons distributed in cytochrome c oxidase, with the metal centers, heme a, heme a3, CuB, the constituents of the catalytic binuclear center. The unusually rapid electron transfer between heme a and heme a3 would have been facilitated by the link pathway of a long sequence of alternate peptide unit and hydrogen bond spanning Pro336-Val374, referred as suprahelix, between these hemes. Two pathways between CuA center and zinc center, share some portions with purported proton-translocating channels, designated "K" and "D".

Item Type:	Article
Depositing User:	Users 2 not found.
Date Deposited:	04 Feb 2019 18:53
Last Modified:	15 Feb 2019 06:13
URI:	http://cdfd.sciencecentral.in/id/eprint/883

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