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Meccariello, A. and Salvemini, M. and Primo, P. and Hall, B. and Koskinioti, P. and Dalíková, M. and Gravina, A. and Gucciardino, M.A. and Forlenza, F. and Gregoriou, M.-E. and Ippolito, D. and Monti, S.M. and Petrella, V. and Perrotta, M.M. and Schmeing, S. and Ruggiero, A. and Scolari, F. and Giordano, E. and Tsoumani, K.T. and Marec, F. and Windbichler, N. and Arunkumar, K.P. and Bourtzis, K. and Mathiopoulos, K.D. and Ragoussis, J. and Vitagliano, L. and Tu, Z. and Papathanos, P.A. and Robinson, M.D. and Saccone, G. (2019) Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests. Science, 365 (6460). pp. 1457-1460. ISSN 0036-8075

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Abstract

In insects, rapidly evolving primary sex-determining signals are transduced by a conserved regulatory module controlling sexual differentiation. In the agricultural pest Ceratitis capitata (Mediterranean fruit fly, Medfly) we identified a Y-linked gene, Maleness-on the-Y (MoY), encoding a small protein that is necessary and sufficient for male development. Silencing or disruption of MoY in XY embryos causes feminization whereas overexpression of MoY in XX embryos induces masculinization. Crosses between transformed XY females and XX males give rise to males and females, indicating that a Y chromosome can be transmitted by XY females. MoY is Y-linked and functionally conserved in other species of the Tephritidae family, highlighting its potential to serve as a tool for developing more effective control strategies against these major agricultural insect pests.

Item Type: Article
Additional Information: This paper is dedicated to the memory of Javaregowda Nagaraju with whom the project was initiated
Subjects: Genetics
Depositing User: Dr P Divakar
Date Deposited: 10 Sep 2019 13:30
Last Modified: 17 Oct 2019 08:52
URI: http://cdfd.sciencecentral.in/id/eprint/920

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