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Verma, Raj Kumar and Biswas, Anindya and Kakkar, Akanksha and Lomada, S.K. and Pradhan, B.B. and Chatterjee, Subhadeep (2020) A Bacteriophytochrome Mediates Interplay between Light Sensing and the Second Messenger Cyclic Di-GMP to Control Social Behavior and Virulence. Cell Reports, 32 (13). p. 108202. ISSN 2211-1247

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Abstract

Bacteriophytochromes are the most abundant and ubiquitous light-sensing receptors in bacteria and are involved in time-of-day behavior or responses. However, their biological and regulatory role in non-photosynthetic bacteria is poorly understood, and even less is known about how they regulate diverse cellular processes. Here, we show that a bacteriophytochrome (XooBphP) from the plant pathogen Xanthomonas oryzae pv. oryzae perceives light signals and transduces a signal through its EAL-mediated phosphodiesterase activity, modulating the intracellular level of the ubiquitous bacterial second messenger c-di-GMP. We discover that light-mediated fine-tuning of intracellular c-di-GMP levels by XooBphP regulates production of virulence functions, iron metabolism, and transition from a sessile to a free-swimming motile lifestyle, contributing to its colonization of the host and virulence. XooBphP thus plays a crucial role in integrating photo-sensing with intracellular signaling to control the pathogenic lifestyle and social behavior.

Item Type: Article
Subjects: Plant Molecular Biology
Depositing User: Dr P. Divakar
Date Deposited: 03 Oct 2020 18:56
Last Modified: 03 Oct 2020 18:56
URI: http://cdfd.sciencecentral.in/id/eprint/975

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