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Jana, Abhimanyu and Aher, Abhishek and Brandao, Paula and Ali, S.S. and Samanta, Sandip Kumar and Mondal, Gopinath and Bera, Pradip and Santra, Ananyakumari and Manna, S.K. and Mahapatra, Ajit Kumar and Bera, Pulakesh (2020) Picoline based fluorescence ‘turn-on’ chemosensor for zinc(II) ion recognition, cell imaging and cytotoxicity study: Synthesis, crystal structure, spectroscopy and DFT. Polyhedron, 192. p. 114815. ISSN 0277-5387

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Abstract

A new picoline based ligand, namely 2-hydroxy-5-methyl-3-[{(6-methylpyridin-2-yl)imino}methyl]benzaldehyde (L) and it’s zinc(II) complex, Zn(L)2 (1) have been synthesized and structurally characterized. The ligand (L) selectively interacts with Zn2+ ion in presence of series of cations in CH3CN-H2O (v/v 1:1) in 1 mM HEPES buffer (pH 7.2). The fluorescence intensity of L is significantly enhanced, and it is increased to 52 times on coordination with Zn(II) ion. The fluorescence intensity value of the L does not show any significant change in the pH range 5 to 9, while the extent of emission phenomenon with Zn(II) ions is observed in the said pH range. The detection limit (0.36 µM) and association constant (log Kapp = 13.25) are evaluated by the fluorescence emission experiment. The probe shows reversibility in addition of dihydrogen phosphate (H2PO4−) ion to the 1. Additionally, the ‘turn-on’ fluorescence probe has sufficient cell permeability and intracellular Zn(II) sensing property as envisaged from the microscopic imaging in HEK293T cells. Both L and ZnL2 (1) are innocuous against PBMC (peripheral blood mononuclear cells) but effective antitumor agents against U-937 cancer cells.

Item Type: Article
Subjects: Molecular Biology
Depositing User: Dr P. Divakar
Date Deposited: 22 Oct 2020 01:49
Last Modified: 22 Oct 2020 01:49
URI: http://cdfd.sciencecentral.in/id/eprint/978

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