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Kasbekar, D.P. (2020) A cross-eyed geneticist’s view VI. Segregation distortion in Drosophila melanogaster: Recent progress in solving ‘an esoteric puzzle’. Journal of Biosciences, 45. e0139. ISSN 0250-5991

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Abstract

Segregation distortion refers to an unusual genetic phenomenon in diploid organisms by which the two alleles at a locus in a parent are not recovered in the classical 1:1 Mendelian ratio in its offspring. The Drosophila melanogaster neogene Sd was created by a duplication breakpoint on the left arm of chromosome 2 (2L), and encodes a truncated RanGAP protein with normal GTPase activity but which mis-localizes to the nucleus and disrupts Ran gradients. Male flies carrying Sd exhibit segregation distortion for the Rsp locus on the right arm of chromosome 2 (2R). Specifically, spermatids inheriting chromosome 2 with the Sd+ Rsps(s) genotype, in heterozygous males of genotype Sd Rspi /Sd+ Rsps(s), fail to develop properly so that the majority of progeny (approaching 100%) carry just the Sd Rspi chromosome. One recent paper reported novel RNAi-expressing transgenes with Sd-mimicking properties; and another reported localization of an X-linked suppressor which restores Mendelian transmission. This article highlights how Drosophila genetics resources made this possible, and the significance of these findings to nucleus-cytoplasm transactions of interest to the wider cell biology community.

Item Type: Article
Subjects: Genetics
Depositing User: Dr P. Divakar
Date Deposited: 13 Nov 2020 19:38
Last Modified: 13 Nov 2020 19:38
URI: http://cdfd.sciencecentral.in/id/eprint/982

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