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Kumar, Raju and Bashyam, M.D. (2017) Multiple oncogenic roles of nuclear β-catenin. Journal of Biosciences, 42 (4). pp. 695-707. ISSN 0250-5991

J Biosci 42 p695.pdf

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β-Catenin is essential for embryonic development and required for cell renewal/regeneration in adult life. Cellular β-catenin exists in three different pools: membranous, cytoplasmic and nuclear. In this review, we focus on functions of the nuclear pool in relation to tumorigenesis. In the nucleus, β-catenin functions as both activator and repressor of transcription in a context-dependent manner. It promotes cell proliferation and supports tumour growth by enhancing angiogenesis. β-Catenin-mediated signalling regulates cancer cell metabolism and is associated with tumour-initiating cells in multiple malignancies. In addition, it functions as both pro- and anti-apoptotic factor besides acting to inhibit recruitment of inflammatory anti-tumour T-cells. Thus, β-catenin appears to possess a multifaceted nuclear function that may significantly impact tumour initiation and progression.

Item Type: Article
Depositing User: Dr P Divakar
Date Deposited: 28 Nov 2017 18:18
Last Modified: 28 Nov 2017 18:18
URI: http://cdfd.sciencecentral.in/id/eprint/813

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