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Raman, R. and Kotapalli, V. and Mohana Vamsy, C. and Patnaik, S.C. and Srinivasulu, M. and Bashyam, M.D. (2014) A positive family history of cancer or lifestyle factors may not explain the high incidence of early-onset colorectal cancer in India. Colorectal Cancer, 3 (5). pp. 409-416. ISSN 1758-194X

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Abstract

Aim: Colorectal cancer (CRC) patients from developing countries such as India exhibit distinct clinico-pathological characteristics including an early age of onset and predominant tumor localization in the rectum. However, the reason(s) for increased occurrence among the young is not clear. Materials & methods: In the current study, we performed a comparative analysis of several epidemiological features in early and late-onset CRC patients from India including association with familial syndromes, diet and lifestyle habits. Results: Surprisingly, there was no significant association of any epidemiological variable with early-onset CRC. Conclusion: Perhaps low penetrance syndromes and/or other genetic causes may be responsible for an early age of onset among Indian CRC patients.

Item Type: Article
Subjects: Molecular Biology
Depositing User: Dr P Divakar
Date Deposited: 24 May 2015 18:56
Last Modified: 24 Sep 2017 10:37
URI: http://cdfd.sciencecentral.in/id/eprint/84

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