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Pradhan, Gourango and Abraham, P.R. and Shrivastava, Rohini and Mukhopadhyay, Sangita (2019) Calcium Signaling Commands Phagosome Maturation Process. International Reviews of Immunology, 38 (2). pp. 57-69. ISSN 0883-0185

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Abstract

Phagosome-lysosome (P-L) fusion is one of the central immune-effector responses of host. It is known that phagosome maturation process is associated with numerous signaling cascades and among these, important role of calcium (Ca2+) signaling has been realized recently. Ca2+ plays key roles in actin rearrangement, activation of NADPH oxidase and protein kinase C (PKC). Involvement of Ca2+ in these cellular processes directs phagosomal maturation process. Some of the intracellular pathogens have acquired the strategies to modulate Ca2+ associated pathways to block P-L fusion process. In this review we have described the mechanism of Ca2+ signals that influence P-L fusion by controlling ROS, actin and PKC signaling cascades. We have also discussed the strategies implemented by the intracellular pathogens to manipulate Ca2+ signaling to consequently subvert P-L fusion. A detail study of factors associated in manipulating Ca2+ signaling may provide new insights for the development of therapeutic tools for more effective treatment options against infectious diseases.

Item Type: Article
Uncontrolled Keywords: Calcium signaling; actin kinetics and PKC signaling; intracellular pathogens; phogosomal maturation; reactive oxygen species
Subjects: Molecular Biology
Depositing User: Dr P Divakar
Date Deposited: 30 May 2019 10:35
Last Modified: 30 May 2019 10:35
URI: http://cdfd.sciencecentral.in/id/eprint/903

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