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Thamban, Thushara and Agarwaal, Viplove and Khosla, Sanjeev (2020) Role of genomic imprinting in mammalian development. Journal of Biosciences, 45 (1). p. 20. ISSN 0250-5991

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Abstract

Non-mendelian inheritance refers to the group of phenomena and observations related to the inheritance of genetic information that cannot be merely explained by Mendel's laws of inheritance. Phenomenon including Genomic imprinting, X-chromosome Inactivation, Paramutations are some of the best studied examples of non-mendelian inheritance. Genomic imprinting is a process that reversibly marks one of the two homologous loci, chromosome or chromosomal sets during development, resulting in functional non-equivalence of gene expression. Genomic imprinting is known to occur in a few insect species, plants, and placental mammals. Over the years, studies on imprinted genes have contributed immensely to highlighting the role of epigenetic modifications and the epigenetic circuitry during gene expression and development. In this review, we discuss the phenomenon of genomic imprinting in mammals and the role it plays especially during fetoplacental growth and early development.

Item Type: Article
Subjects: Genetics
Depositing User: Dr P Divakar
Date Deposited: 05 Feb 2020 19:38
Last Modified: 05 Feb 2020 19:56
URI: http://cdfd.sciencecentral.in/id/eprint/939

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