Frankel, W.N. and Bashyam, M.D. and Kwei, K.A. and Kao, J. and Ratheesh, R. and Reddy, E.C. and Kim, Y.H. and Montgomery, K. and Giacomini, C.P. and Choi, Y.-L. and Chatterjee, Sreejata and Karikari, C.A. and Salari, K. and Wang, P. and Hernandez-Boussard, T. and Gowrishankar, S. and van de Rijn, M. and Maitra, A. and Pollack, J.R. (2008) Genomic Profiling Identifies GATA6 as a Candidate Oncogene Amplified in Pancreatobiliary Cancer. PLoS Genetics, 4 (5). e1000081. ISSN 1553-7404

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Abstract

Pancreatic cancer is a devastating disease, having among the lowest survival rates of any cancer. A better understanding of the molecular basis of pancreatic cancer may lead to improved rationale therapies. We report here the discovery of amplification (i.e. extra copies) of the GATA6 gene in many human pancreatic cancers. GATA6 is a regulator of gene expression and functions in the development of the normal pancreas. Our findings indicate that its amplification and aberrant overexpression contribute to pancreatic cancer development. GATA6 joins a growing list of cancer genes with key roles in normal human development but pathogenic roles in cancer when aberrantly expressed. Our discovery of GATA6 amplification provides a new foothold into understanding the pathogenic mechanisms underlying pancreatic cancer, and suggests new strategies for therapy by targeting GATA6 or the genes it regulates

Item Type:	Article
Depositing User:	Users 2 not found.
Date Deposited:	25 Aug 2015 09:09
Last Modified:	28 Nov 2015 19:03
URI:	http://cdfd.sciencecentral.in/id/eprint/377

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