Pasha, J. and Bhaskar, K. and Sen, S. and Seerapu, G.P.K. and Bujji, S. and Haldar, Devyani and Srinivas, N. and Srinivas, O. (2015) Amberlyst-15 catalyzed Povarov reaction of N-arylidene-1H-indazol-6-amines and indoles: a greener approach to the synthesis of exo-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinolines as potential sirtuin inhibitors. Tetrahedron Letters, 56 (18). pp. 2289-2292. ISSN 0040-4039

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Abstract

Amberlyst 15(H) has been shown for the first time to be effective as a greener catalyst in promoting the Povarov reaction between an imine, derived from the aryl/heteroaryl aldehydes and 1H-indazol-6-amine, and indole/5-bromo-1H-indole. Representative candidates from the library of exo-1,6,7,7a,12,12a-hexahydroindolo[ 3,2-c]pyrazolo[3,4-f]quinolines, thus synthesized, were tested for their sirtuin (Sir-2) inhibitory activity using a yeast based assay. Among the ten compounds investigated in the assay, those derived from 5-bromoindole exhibited a higher degree of Sir-2 inhibition as compared to their analogs, derived from indole.

Item Type:	Article
Uncontrolled Keywords:	Povarov reaction; Amberlyst-15; Hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinolines; Sirtuin inhibitors; Yeast assay
Depositing User:	Users 2 not found.
Date Deposited:	16 May 2015 19:36
Last Modified:	16 Dec 2015 08:36
URI:	http://cdfd.sciencecentral.in/id/eprint/39

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