Dutta, Usha and Rajitha, Ponnala and Vijaya Kumar, P. and Dalal, Ashwin (2011) Cytogenetic abnormalities in 1162 couples with recurrent miscarriages in Southern region of India: report and review. Journal of Assisted Reproduction and Genetics, 28 (2). pp. 145-149. ISSN 1058-0468

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Abstract

Purpose The purpose of the present study was to investigate the contribution of chromosomal anomalies and the frequency of a particular type of aberration in couples with recurrent miscarriages. Methods A total of 1,162 couples with recurrent miscarriages were analyzed using G-banding and Fluorescence in situ hybridization where ever necessary. Results Chromosomal anomalies were detected in 78 cases. This study describes majority of the cases with balanced reciprocal translocations. Among the abnormal karyotypes we also report for the first time three unique translocations involving (3;14), (18;22) and (X;22) chromosomes which were confirmed by molecular cytogenetic methods. Conclusions The review of literature and the overall incidence of the abnormalities suggest that chromosomal analysis in couples with recurrent miscarriages should be taken up by all the practioners at all levels. This not only helps to check the cytological abnormalities but also helps to correlate the recurrent abnormalities in a given population. Thus establishing and correlating the environmental and genetic condition of that particular phenotype and genotype

Item Type:	Article
Additional Information:	[Open Access through PubMed Central] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059523/
Depositing User:	Users 2 not found.
Date Deposited:	02 Sep 2015 04:28
Last Modified:	15 Dec 2015 11:07
URI:	http://cdfd.sciencecentral.in/id/eprint/436

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