Ali, J. and Shashi Rekha, T. and Ranjan, Akash (2012) The parasite specific substitution matrices improve the annotation of apicomplexan proteins. BMC genomics, 13 (Suppl ). S19. ISSN 1471-2164

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Abstract

A number of apicomplexan genomes have been sequenced successfully in recent years and this would help in understanding the biology of apicomplexan parasites. The members of the phylum Apicomplexa are important protozoan parasites (Plasmodium, Toxoplasma and Cryptosporidium etc) that cause some of the deadly diseases in humans and animals. In our earlier studies, we have shown that the standard BLOSUM matrices are not suitable for compositionally biased apicomplexan proteins. So we developed a novel series (SMAT and PfFSmat60) of substitution matrices which performed better in comparison to standard BLOSUM matrices and developed ApicoAlign, a sequence search and alignment tool for apicomplexan proteins. In this study, we demonstrate the higher specificity of these matrices and make an attempt to improve the annotation of apicomplexan kinases and proteases.

Item Type:	Article
Depositing User:	Users 2 not found.
Date Deposited:	11 Sep 2015 09:02
Last Modified:	08 Oct 2015 06:11
URI:	http://cdfd.sciencecentral.in/id/eprint/493

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