Mukhopadhyay, Sangita and Ghosh, Sudip (2017) Mycobacterium tuberculosis: what is the role of PPE2 during infection? Future Microbiology, 12 (6). pp. 457-460. ISSN 1746-0913

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Abstract

PPE2 appears to be secreted into the host cytoplasm during Mtb infection, translocated to the nucleus where it binds to the GATA-1 elements present in the inos promoter and sterically inhibits recruitment of the transcription machinery to inhibit transcription of inos gene. However, the exact mechanism of its interaction with the transcription machinery is yet to be understood. Since several essential gene transcriptions are also controlled by GATA-1 transcription factors, it is possible that PPE2 is selectively recruited only to those genes required to be inhibited for successful pathogenesis.

Item Type:	Article
Depositing User:	Users 2 not found.
Date Deposited:	12 May 2017 06:56
Last Modified:	29 May 2017 18:46
URI:	http://cdfd.sciencecentral.in/id/eprint/777

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