Srivastava, Varsha and Surekha Rani, H. and Kumawat, R.K. and Chaubey, Gyaneshwer and Shrivastava, Pankaj (2020) Genomic diversity of the Muslim population from Telangana (India) inferred from 23 autosomal STRs. Annals of Human Biology. ISSN 0301-4460 (In Press)

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Abstract

Aim: This study aimed to investigate the genomic diversity and population structure in the Muslim community of Telangana, India, using 23 autosomal microsatellite genetic markers. We also examined genetic relatedness between Muslim and non-Muslim populations of India. Subjects and methods: A sample of randomly selected184 unrelated healthy Muslim individuals from the Telangana state were included in this study. The genotyping of 23 autosomal STR markers included in PowerPlex® Fusion 6C multiplex system (Promega)was done. Results: A total of 273 alleles were observed in the studied population, and locus SE33 showed 37 observed alleles, which is the highest number of observed alleles among all the studied loci. Among all the studied loci the most polymorphic and discriminatory locus was SE33, with the values of polymorphic information content (PIC) = 9.411E-01 and power of discrimination (PD) = 9.865E-01. Observed heterozygosity ranged from 6.630E-01 (D22S1045) to 9.239E-01 (SE33). Discrimination power, exclusion power, matching probability and paternity index for all the studied loci were 1.00E + 00, 1.00E + 00, 2.01E-28, and 5.68E + 09,respectively.The studied Muslim population showed genetic relatedness with non-Muslim populations i.e. populations of central India, Jharkhand, and Uttar Pradesh, suggesting the conversion of Hindus during the Muslim invasion. Conclusion: Neighbor-joining (NJ) tree and principal component analysis (PCA) revealed that the studied population showed genetic affinity with communities of Jharkhand, Madhya Pradesh and Uttar Pradesh states. The genetic data of this study may be useful for forensic, medical, and anthropological studies.

Item Type:	Article
Subjects:	Genetics
Depositing User:	Users 2 not found.
Date Deposited:	24 Sep 2020 20:02
Last Modified:	24 Sep 2020 20:02
URI:	http://cdfd.sciencecentral.in/id/eprint/973

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